Publication

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM

The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins and define a function in sensing of viral DNA for the previously uncharacterized IFIX protein. By designing a cell-based inducible ... [more]

Quantitative Score

• 0.98175 [Saint Score]

Throughput

• High Throughput

Additional Notes

• note, however, that inclusion of interactors in the article was dependent on more complex criteria than that single averaged SAINT score
• the indicated score for the interactor/prey protein is the average of SAINT scores for that interactor from affinity purification experiments using both N- and C-terminally tagged constructs of the indicated bait protein

Curated By

• BioGRID