BAIT
ECT2
AI528536, mKIAA4037
ect2 oncogene
GO Process (20)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- activation of Rac GTPase activity [ISO]
- activation of Rho GTPase activity [ISO]
- activation of protein kinase activity [ISO]
- cell morphogenesis [IDA]
- cellular response to calcium ion [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to ionizing radiation [ISO]
- cytokinesis [ISO]
- positive regulation of Cdc42 GTPase activity [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of protein import into nucleus [IDA]
- protein homooligomerization [ISO]
- regulation of attachment of spindle microtubules to kinetochore [ISO]
- regulation of protein kinase activity [ISO]
- signal transduction [ISO]
- tight junction assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ERLIN1
C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62, RP11-316M21.1
ER lipid raft associated 1
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and ... [more]
Nat. Cell Biol. Dec. 01, 2019; 22(4);498-511 [Pubmed: 32203420]
Quantitative Score
- 9.811029654 [CompPASS Z-score]
Throughput
- High Throughput
Additional Notes
- prey proteins were classified into confidence-level categories of gold (highest confidence), silver or bronze based on various criteria
- tagged bait proteins were affinity purified and associated proteins identified by mass spectrometry
- the score provided is the CompPASS Z-score
- this interaction was classified by the authors as being in the gold list
Curated By
- BioGRID