BAIT
OPHN1
C130037N19Rik, RP23-48E15.3
oligophrenin 1
GO Process (6)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PPIF
CYP3, CyP-M, Cyp-D, CypD, RP11-342M3.4
peptidylprolyl isomerase F
GO Process (15)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cellular response to arsenic-containing substance [ISS]
- cellular response to calcium ion [ISS]
- cellular response to hydrogen peroxide [IMP]
- negative regulation of ATPase activity [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of oxidative phosphorylation [ISS]
- negative regulation of oxidative phosphorylation uncoupler activity [ISS]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of mitochondrial membrane permeability [ISS]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IMP]
- regulation of proton-transporting ATPase activity, rotational mechanism [ISS]
- response to ischemia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and ... [more]
Nat. Cell Biol. Dec. 01, 2019; 22(4);498-511 [Pubmed: 32203420]
Quantitative Score
- 5.7006491 [CompPASS Z-score]
Throughput
- High Throughput
Additional Notes
- prey proteins were classified into confidence-level categories of gold (highest confidence), silver or bronze based on various criteria
- tagged bait proteins were affinity purified and associated proteins identified by mass spectrometry
- the score provided is the CompPASS Z-score
- this interaction was classified by the authors as being in the gold list
Curated By
- BioGRID