BAIT
ABR
RP23-48B14.2
active BCR-related gene
GO Process (11)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- actin cytoskeleton organization [IGI]
- brain development [IGI]
- inner ear morphogenesis [IGI]
- negative regulation of cell migration [IGI]
- negative regulation of inflammatory response [IMP]
- negative regulation of neutrophil degranulation [IGI]
- neuromuscular process controlling balance [IGI]
- positive regulation of GTPase activity [TAS]
- positive regulation of Rac GTPase activity [IGI]
- positive regulation of phagocytosis [IGI]
- response to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
PRRC2A
BAT2, D6S51, D6S51E, G2, DADB-70P7.5
proline-rich coiled-coil 2A
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and ... [more]
Nat. Cell Biol. Dec. 01, 2019; 22(4);498-511 [Pubmed: 32203420]
Quantitative Score
- 2.549254234 [CompPASS Z-score]
Throughput
- High Throughput
Additional Notes
- prey proteins were classified into confidence-level categories of gold (highest confidence), silver or bronze based on various criteria
- tagged bait proteins were affinity purified and associated proteins identified by mass spectrometry
- the score provided is the CompPASS Z-score
- this interaction was classified by the authors as being in the bronze list
Curated By
- BioGRID