BAIT
INPP5B
5PTase, AW260155, INPP5P, RP23-168M5.1
inositol polyphosphate-5-phosphatase B
GO Process (6)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
RAB6A
RAB6
RAB6A, member RAS oncogene family
GO Process (10)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [IMP]
- early endosome to Golgi transport [IMP]
- minus-end-directed organelle transport along microtubule [TAS]
- peptidyl-cysteine methylation [IDA]
- protein localization to Golgi apparatus [IDA]
- protein targeting to Golgi [IDA]
- retrograde transport, endosome to Golgi [IBA]
- retrograde vesicle-mediated transport, Golgi to ER [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a family-wide characterization of substrate specificities, interactomes and localization, we reveal at the systems level how RhoGEFs and ... [more]
Nat. Cell Biol. Dec. 01, 2019; 22(4);498-511 [Pubmed: 32203420]
Quantitative Score
- 3.641210528 [CompPASS Z-score]
Throughput
- High Throughput
Additional Notes
- prey proteins were classified into confidence-level categories of gold (highest confidence), silver or bronze based on various criteria
- tagged bait proteins were affinity purified and associated proteins identified by mass spectrometry
- the score provided is the CompPASS Z-score
- this interaction was classified by the authors as being in the bronze list
Curated By
- BioGRID