CDK7
Gene Ontology Biological Process
- mitotic nuclear division [IMP]
- programmed cell death [IMP]
- promoter clearance from RNA polymerase II promoter [IDA]
- protein phosphorylation [IDA, NAS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DCAF12
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus.
Hippo signaling controls organ size and tumor progression through a conserved pathway leading to nuclear translocation of the transcriptional effector Yki/Yap/Taz. Most of our understanding of Hippo signaling pertains to its cytoplasmic regulation, but how the pathway is controlled in the nucleus remains poorly understood. Here we uncover an evolutionarily conserved mechanism by which CDK7 promotes Yki/Yap/Taz stabilization in the ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of DCAF12 not clear
Curated By
- BioGRID