BAIT
AUH
AU RNA binding protein/enoyl-CoA hydratase
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPIF
CYP3, CyP-M, Cyp-D, CypD, RP11-342M3.4
peptidylprolyl isomerase F
GO Process (15)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cellular response to arsenic-containing substance [ISS]
- cellular response to calcium ion [ISS]
- cellular response to hydrogen peroxide [IMP]
- negative regulation of ATPase activity [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of oxidative phosphorylation [ISS]
- negative regulation of oxidative phosphorylation uncoupler activity [ISS]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of mitochondrial membrane permeability [ISS]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IMP]
- regulation of proton-transporting ATPase activity, rotational mechanism [ISS]
- response to ischemia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID