BAIT
ESA1
TAS1, NuA4 histone acetyltransferase complex catalytic subunit ESA1, KAT5, L000003952, YOR244W
Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases
GO Process (10)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- DNA repair [IDA, IMP]
- DNA-templated transcription, elongation [IDA, IMP]
- chromatin organization involved in regulation of transcription [IMP]
- chromatin silencing at rDNA [IGI, IMP]
- histone acetylation [IDA]
- peptidyl-lysine acetylation [IMP]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IGI, IMP]
- regulation of cell cycle [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
ECM7
ZRG15, L000003882, YLR443W
Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular ... [more]
Genes Dev. Aug. 01, 2008; 22(15);2062-74 [Pubmed: 18676811]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: dSLAM analysis was performed to determine genome-wide genetic interaction profiles of 38 query genes involved in histone (de)acetylation.
- Low Throughput: Genetic interactions identified using dSLAM were validated by tetrad dissection and/or random spore analysis.
Curated By
- BioGRID