BAIT
C1QBP
GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
complement component 1, q subcomponent binding protein
GO Process (21)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- immune response [TAS]
- mature ribosome assembly [IMP]
- negative regulation of MDA-5 signaling pathway [IDA]
- negative regulation of RIG-I signaling pathway [IDA]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of mitochondrial translation [ISS]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of trophoblast cell migration [IMP]
- regulation of complement activation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PNPT1
COXPD13, DFNB70, OLD35, PNPASE, old-35
polyribonucleotide nucleotidyltransferase 1
GO Process (24)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA catabolic process [IDA]
- RNA import into mitochondrion [IDA]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IDA]
- RNA polyadenylation [IDA]
- cellular response to interferon-beta [IDA]
- cellular response to oxidative stress [IDA]
- mRNA catabolic process [IDA]
- mitochondrial RNA 3'-end processing [IMP]
- mitochondrial RNA 5'-end processing [IMP]
- mitochondrial RNA catabolic process [IDA]
- mitochondrial mRNA catabolic process [IDA]
- mitochondrial mRNA polyadenylation [IMP]
- mitochondrion morphogenesis [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of growth [IDA]
- nuclear polyadenylation-dependent mRNA catabolic process [IDA]
- positive regulation of mRNA catabolic process [IMP]
- positive regulation of miRNA catabolic process [IDA]
- positive regulation of mitochondrial RNA catabolic process [IDA]
- protein homooligomerization [IDA]
- protein homotrimerization [IDA]
- rRNA import into mitochondrion [IDA]
- regulation of cellular respiration [ISS]
- regulation of cellular senescence [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID