BAIT

OSTM1

GIPN, GL, OPTB5, HSPC019
osteopetrosis associated transmembrane protein 1
UPS Project
GO Process (2)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

RGS17

RGS-17, RGSZ2, hRGS17
regulator of G-protein signaling 17
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.

Fischer T, De Vries L, Meerloo T, Farquhar MG

We have isolated an RGS-GAIP interacting protein that links RGS proteins to protein degradation. GIPN (GAIP interacting protein N terminus) is a 38-kDa protein with an N-terminal leucine-rich region, a central RING finger-like domain, and a putative C-terminal transmembrane domain. GIPN binds exclusively to RGS proteins of subfamily A, RGS-GAIP, RGSZ1, and RGSZ2. The N-terminal leucine-rich region of GIPN interacts ... [more]

Proc. Natl. Acad. Sci. U.S.A. Jul. 08, 2003; 100(14);8270-5 [Pubmed: 12826607]

Throughput

  • Low Throughput

Curated By

  • BioGRID