BAIT
MDH2
M-MDH, MDH, MGC:3559, MOR1
malate dehydrogenase 2, NAD (mitochondrial)
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SUPV3L1
SUV3, RP11-227H15.2
suppressor of var1, 3-like 1 (S. cerevisiae)
GO Process (14)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IMP]
- DNA recombination [IMP]
- RNA catabolic process [IMP]
- chromatin maintenance [IMP]
- mitochondrial RNA 3'-end processing [IMP]
- mitochondrial RNA surveillance [IMP]
- mitochondrial mRNA catabolic process [IMP]
- mitochondrial mRNA surveillance [IMP]
- mitochondrial ncRNA surveillance [IMP]
- mitochondrion morphogenesis [IMP]
- negative regulation of apoptotic process [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of mitochondrial RNA catabolic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 0.98 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID