BAIT
MTCH1
CGI-64, PIG60, PSAP, SLC25A49, RP1-90K10.1
mitochondrial carrier 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRKCQ
PRKCT, nPKC-theta, RP11-563J2.1
protein kinase C, theta
GO Process (25)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- innate immune response [TAS]
- intracellular signal transduction [NAS]
- membrane protein ectodomain proteolysis [ISS]
- negative regulation of T cell apoptotic process [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [ISS]
- positive regulation of T-helper 17 type immune response [ISS]
- positive regulation of T-helper 2 cell activation [ISS]
- positive regulation of interleukin-17 production [ISS]
- positive regulation of interleukin-4 production [ISS]
- protein ubiquitination [TAS]
- regulation of cell growth [NAS]
- regulation of platelet aggregation [ISS]
- regulation of rhodopsin mediated signaling pathway [TAS]
- regulation of transcription, DNA-templated [ISS]
- rhodopsin mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID