BAIT
YAF9
S000007495, YNL107W
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain
GO Process (4)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
ARG82
ARGR3, IPK2, inositol polyphosphate multikinase, ARGRIII, L000002727, YDR173C
Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
GO Process (6)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- inositol phosphate biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- phosphatidylinositol phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein stabilization [IMP]
- regulation of arginine metabolic process [IMP]
Gene Ontology Molecular Function- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular ... [more]
Genes Dev. Aug. 01, 2008; 22(15);2062-74 [Pubmed: 18676811]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: dSLAM analysis was performed to determine genome-wide genetic interaction profiles of 38 query genes involved in histone (de)acetylation.
- Low Throughput: Genetic interactions identified using dSLAM were validated by tetrad dissection and/or random spore analysis.
Curated By
- BioGRID