BAIT
SLC25A46
solute carrier family 25, member 46
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
KIF16B
C20orf23, KISC20ORF, SNX23, RP5-971B4.1
kinesin family member 16B
GO Process (10)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- Golgi to endosome transport [ISS]
- early endosome to late endosome transport [IMP]
- endoderm development [ISS]
- epidermal growth factor receptor signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [ISS]
- formation of primary germ layer [ISS]
- microtubule-based movement [IBA]
- receptor catabolic process [IMP]
- regulation of receptor recycling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 0.89 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID