BAIT
TFAM
MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3
transcription factor A, mitochondrial
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- DNA-dependent DNA replication [TAS]
- chromatin remodeling [IBA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase I promoter [TAS]
- transcription from mitochondrial promoter [IMP, TAS]
- transcription initiation from mitochondrial promoter [IDA, TAS]
Gene Ontology Molecular Function- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- chromatin binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- chromatin binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
MRPS25
MRP-S25, RPMS25
mitochondrial ribosomal protein S25
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A High-Density Human Mitochondrial Proximity Interaction Network.
We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from all mitochondrial sub-compartments, to create a high-resolution human mitochondrial proximity interaction network. We identified 1,465 proteins, producing 15,626 unique high-confidence proximity interactions. Of these, 528 proteins were previously annotated as mitochondrial, nearly half of the mitochondrial proteome defined by Mitocarta 2.0. Bait-bait analysis showed a clear separation of ... [more]
Cell Metab. Sep. 01, 2020; 32(3);479-497.e9 [Pubmed: 32877691]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- interaction assayed using BioID
- interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less
- the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown
Curated By
- BioGRID