BAIT
ARHGAP17
MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH-1, RICH1, WBP15, hCG_1984576
Rho GTPase activating protein 17
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.
A previously unidentified Rho GTPase-activating protein (GAP) domain-containing protein was found in a yeast two-hybrid screen for cDNAs encoding proteins binding to the Src homology 3 domain of Cdc42-interacting protein 4 (CIP4). The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal ... [more]
J. Biol. Chem. Sep. 14, 2001; 276(37);35060-70 [Pubmed: 11431473]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PACSIN1 ARHGAP17 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID