BAIT

RGS5

MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, RP11-267N12.3
regulator of G-protein signaling 5
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GNAO1

EIEE17, G-ALPHA-o, GNAO
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.

Chen C, Zheng B, Han J, Lin SC

Genetic studies of molecules that negatively regulate G-coupled receptor functions have led to the identification of a large gene family with an evolutionarily conserved domain, termed the RGS domain. It is now understood that RGS proteins serve as GTPase-activating proteins for subfamilies of the heterotrimeric G-proteins. We have isolated from mouse pituitary a full-length cDNA clone encoding a novel member ... [more]

J. Biol. Chem. Mar. 28, 1997; 272(13);8679-85 [Pubmed: 9079700]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RGS5 GNAO1
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-

Curated By

  • BioGRID