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BAIT

EPHB1

Ephb2, Erk, elk

Eph receptor B1

GO Process (23)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

angiogenesis [ISO, ISS]

axon guidance [ISO, ISS]

camera-type eye morphogenesis [ISO]

cell chemotaxis [ISO, ISS]

cell-substrate adhesion [ISO, ISS]

central nervous system projection neuron axonogenesis [ISO, ISS]

cranial nerve development [ISO]

dendritic spine development [ISO, ISS]

dendritic spine morphogenesis [ISO, ISS]

detection of temperature stimulus involved in sensory perception of pain [ISO, ISS]

ephrin receptor signaling pathway [ISO, ISS]

establishment of cell polarity [ISO, ISS]

neural precursor cell proliferation [ISO, ISS]

neurogenesis [ISO, ISS]

optic nerve morphogenesis [ISO]

peptidyl-tyrosine phosphorylation [IDA, IMP]

positive regulation of synapse assembly [ISO, ISS]

protein autophosphorylation [IDA, ISO]

regulation of ERK1 and ERK2 cascade [ISO, ISS]

regulation of JNK cascade [ISO, ISS]

regulation of neuron death [ISO]

retinal ganglion cell axon guidance [ISO, ISS]

signal transduction [ISO]

Gene Ontology Molecular Function

axon guidance receptor activity [ISO]
protein complex binding [ISO]
protein tyrosine kinase activity [IDA, IMP]
transmembrane-ephrin receptor activity [ISO, ISS]

Gene Ontology Cellular Component

cytoplasm [ISO]

early endosome membrane [ISO, ISS]

extracellular vesicular exosome [ISO]

filopodium tip [ISO]

integral component of plasma membrane [ISO, ISS]

membrane raft [ISO]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

PREY

EFNB2

EPLG5, HTKL, Htk-L, LERK5, RP11-272L14.1

ephrin-B2

GO Process (8)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

anatomical structure morphogenesis [TAS]

axon guidance [IBA]

cell adhesion [IDA]

cell migration involved in sprouting angiogenesis [IDA]

cell-cell signaling [TAS]

ephrin receptor signaling pathway [IDA]

positive regulation of cardiac muscle cell differentiation [ISS]

regulation of chemotaxis [IDA]

Gene Ontology Molecular Function

ephrin receptor binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

focal adhesion [IDA]

integral component of plasma membrane [TAS]

plasma membrane [IBA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.

Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ

Hek and elk are members of the eph-related family of receptor tyrosine kinases. Recently we isolated four cDNAs encoding membrane-bound ligands to hek and elk [Beckman et al. (1994) EMBO J. 13, 3757-3762; Kozlosky et al. (1995) Oncogene 10, 299-306]. Because of the promiscuous nature of their binding, we have termed these proteins ligands of the eph-related kinases or LERKs. ... [more]

Mol. Immunol. Nov. 01, 1995; 32(16);1197-205 [Pubmed: 8559144]

Throughput

Low Throughput

Curated By

BioGRID