VCAM1
Gene Ontology Biological Process
- B cell differentiation [IC]
- amine metabolic process [IDA]
- cell adhesion [IDA]
- cell-matrix adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte tethering or rolling [IDA, IEP]
- membrane to membrane docking [IEP]
- oxidation-reduction process [IDA]
- positive regulation of T cell proliferation [IDA]
- regulation of immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [IDA]
- apical part of cell [IDA]
- cell surface [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- microvillus [IDA]
- plasma membrane [TAS]
- podosome [IDA]
EZR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- actin filament [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [ISS]
- cell periphery [IDA]
- cortical cytoskeleton [TAS]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- extrinsic component of membrane [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- microvillus [IDA]
- nucleolus [IDA]
- plasma membrane [IDA]
- ruffle [IDA]
- vesicle [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.
Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by connecting membrane adhesion receptors to the actin-based cytoskeleton. We have studied the interaction of moesin and ezrin with the vascular cell adhesion molecule (VCAM)-1 during leukocyte adhesion and transendothelial migration (TEM). VCAM-1 interacted directly with moesin and ezrin in vitro, and all of these molecules colocalized at the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VCAM1 EZR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID