BAIT
ACACA
ACAC, ACACAD, ACC, ACC1, ACCA
acetyl-CoA carboxylase alpha
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISS]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- fatty acid biosynthetic process [ISS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PRELID1
PRELI, PX19, SBBI12, CGI-106
PRELI domain containing 1
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- immune response [TAS]
- multicellular organismal development [TAS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of mitochondrial membrane potential [IDA]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- phospholipid transport [IMP]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of cellular respiration [IDA]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of phospholipid transport [IDA]
- regulation of T cell differentiation [IDA]
- regulation of membrane lipid distribution [IDA]
- regulation of mitochondrial membrane potential [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.
The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases, including cancer. Because cancer cells are intrinsically buffered to combat metabolic stress, it is important to understand how cells may adapt to the loss of de novo fatty acid biosynthesis. Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in ... [more]
Nat Metab Jun. 01, 2020; 2(6);499-513 [Pubmed: 32694731]
Throughput
- High Throughput
Ontology Terms
- phenotype: viability (PATO:0000169)
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line: HAP1
- Experimental Setup: Timecourse
- GIST: A-phenotypic positive genetic interaction
- Library: TKOv3
- Significance Threshold: -0.5>qGI>0.5; false-discovery rate (FDR)<0.5
Curated By
- BioGRID