BAIT

ABL1

ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl, RP11-83J21.1
ABL proto-oncogene 1, non-receptor tyrosine kinase
GO Process (40)
GO Function (16)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.

Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB

Proteins of the Ena/VASP family are implicated in processes that require dynamic actin remodeling such as axon guidance and platelet activation. In this work, we explored some of the pathways that likely regulate actin dynamics in part via EVL (Ena/VASP-like protein). Two isoforms, EVL and EVL-I, were highly expressed in hematopoietic cells of thymus and spleen. In CD3-activated T-cells, EVL ... [more]

J. Biol. Chem. Nov. 17, 2000; 275(46);36143-51 [Pubmed: 10945997]

Throughput

  • Low Throughput

Curated By

  • BioGRID