SRI
Gene Ontology Biological Process
- action potential [TAS]
- intracellular sequestering of iron ion [TAS]
- muscle organ development [TAS]
- negative regulation of heart rate [IMP]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- proteolysis [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling [TAS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IMP]
- regulation of heart contraction [TAS]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of relaxation of muscle [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of striated muscle contraction [TAS]
- signal transduction [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SRI
Gene Ontology Biological Process
- action potential [TAS]
- intracellular sequestering of iron ion [TAS]
- muscle organ development [TAS]
- negative regulation of heart rate [IMP]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- proteolysis [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling [TAS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IMP]
- regulation of heart contraction [TAS]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of relaxation of muscle [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of striated muscle contraction [TAS]
- signal transduction [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.
Sorcin is a 22 kD calcium-binding protein that is found in a wide variety of cell types, such as heart, muscle, brain and adrenal medulla. It belongs to the penta-EF-hand (PEF) protein family, which contains five EF-hand motifs that associate with membranes in a calcium-dependent manner. Prototypic members of this family are the calcium-binding domains of calpain, such as calpain ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRI SRI | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| SRI SRI | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID