CD34
Gene Ontology Biological Process
- cell motility [IEP]
- cell proliferation [ISS]
- endothelial cell proliferation [IDA]
- endothelium development [IEP]
- extracellular vesicular exosome assembly [IDA]
- glomerular endothelium development [IEP]
- glomerular filtration [IEP]
- hematopoietic stem cell proliferation [IMP]
- hemopoiesis [IMP]
- leukocyte migration [ISS]
- mesangial cell-matrix adhesion [ISS]
- metanephric glomerular mesangial cell differentiation [IEP]
- negative regulation of blood coagulation [IDA]
- negative regulation of cellular response to heat [IDA]
- negative regulation of cellular response to hypoxia [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of interleukin-2 secretion [IMP]
- negative regulation of neuron death [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- paracrine signaling [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of gene expression [IEP]
- positive regulation of glial cell line-derived neurotrophic factor secretion [IDA]
- positive regulation of granulocyte colony-stimulating factor production [IDA, IEP]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of odontogenesis [IDA]
- positive regulation of transforming growth factor beta production [IDA]
- positive regulation of vasculogenesis [IDA]
- regulation of blood pressure [IDA]
- regulation of immune response [TAS]
- signal transduction [IEP]
- single organismal cell-cell adhesion [IDA]
- stem cell proliferation [IEP]
- tissue homeostasis [IDA]
- transdifferentiation [IEP]
- vascular wound healing [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CRKL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The adapter protein CrkL associates with CD34.
CD34 is a cell-surface transmembrane protein expressed specifically at the stem/progenitor stage of lymphohematopoietic development that appears to regulate adhesion. To elucidate intracellular signals modified by CD34, we designed and constructed glutathione-S-transferase (GST)- fusion proteins of the intracellular domain of full-length CD34 (GST-CD34i(full)). Precipitation of cell lysates using GST-CD34i(full) identified proteins of molecular mass 39, 36, and 33 kd that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD34 CRKL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID