Synaptotagmins (Syts) are a large family of membrane proteins consisted of at least 12 isoforms. They are categorized in neuron-specific isoforms (I-V, X, and XI) and ubiquitous isoforms (VI-IX) based on their expression patterns. Syt-I, a neuron-specific and abundant isoform, has been well characterized and postulated to be the exocytotic Ca(2+) sensor. However, the functions of other isoforms remain obscure. ... [more]

J. Biol. Chem. Mar. 31, 2000; 275(13);9823-31 [Pubmed: 10734137]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

SYT1

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol binding [TAS]SNARE binding [ISS]calcium-dependent phospholipid binding [ISS, TAS]low-density lipoprotein particle receptor binding [IDA]protein binding [IPI]syntaxin-1 binding [ISS, TAS]

Gene Ontology Cellular Component

SYNCRIP

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]poly(A) RNA binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Reconstituted Complex

Publication

SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.

Throughput

Curated By

1-phosphatidylinositol binding [TAS]
SNARE binding [ISS]
calcium-dependent phospholipid binding [ISS, TAS]
low-density lipoprotein particle receptor binding [IDA]
protein binding [IPI]
syntaxin-1 binding [ISS, TAS]

RNA binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]