BAIT
KCNB1
DRK1, EIEE26, KV2.1, h-DRK1
potassium voltage-gated channel, Shab-related subfamily, member 1
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNAP25
RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2
synaptosomal-associated protein, 25kDa
GO Process (11)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- energy reserve metabolic process [TAS]
- glutamate secretion [TAS]
- neurotransmitter secretion [TAS]
- neurotransmitter uptake [NAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [NAS, TAS]
- synaptic vesicle docking [NAS]
- synaptic vesicle exocytosis [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
Insulin secretion is initiated by ionic events involving membrane depolarization and Ca(2+) entry, whereas exocytic SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins mediate exocytosis itself. In the present study, we characterize the interaction of the SNARE protein SNAP-25 (synaptosome-associated protein of 25 kDa) with the beta-cell voltage-dependent K(+) channel Kv2.1. Expression of Kv2.1, SNAP-25, and syntaxin 1A was detected ... [more]
Mol. Endocrinol. Nov. 01, 2002; 16(11);2452-61 [Pubmed: 12403834]
Throughput
- Low Throughput
Curated By
- BioGRID