BAIT
DP
49Fk, CG4654, DDP1, DP1, DmDP, Dmel\CG4654, TFPD2, dDP, l(2)49Fk, l(2)vr10, vr10, Dmel_CG4654
DP transcription factor
GO Process (11)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
- eggshell chorion gene amplification [TAS]
- endomitotic cell cycle [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- mitotic cell cycle [IMP]
- nurse cell apoptotic process [TAS]
- oogenesis [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of nurse cell apoptotic process [IMP]
- regulation of cell cycle [IMP, NAS]
- regulation of transcription from RNA polymerase II promoter [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
E2F2
CG1071, Dmel\CG1071, E2F, dE2F-2, dE2F2, Dmel_CG1071
E2F transcription factor 2
GO Process (11)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- DNA endoreduplication [IGI, IMP]
- G1/S transition of mitotic cell cycle [TAS]
- endomitotic cell cycle [TAS]
- imaginal disc development [TAS]
- negative regulation of DNA replication [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [TAS]
- oocyte anterior/posterior axis specification [IMP]
- oocyte dorsal/ventral axis specification [IMP]
- oogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor networks in Drosophila melanogaster.
Specific cellular fates and functions depend on differential gene expression, which occurs primarily at the transcriptional level and is controlled by complex regulatory networks of transcription factors (TFs). TFs act through combinatorial interactions with other TFs, cofactors, and chromatin-remodeling proteins. Here, we define protein-protein interactions using a coaffinity purification/mass spectrometry method and study 459 Drosophila melanogaster transcription-related factors, representing approximately ... [more]
Cell Rep Sep. 25, 2014; 8(6);2031-43 [Pubmed: 25242320]
Quantitative Score
- 27.666433 [HGSCore]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified using a HyperGeometric Spectral Counts scoring method (HGSCore) and were filtered to a false discovery rate (FDR) of 2%.
Related interactions
Curated By
- BioGRID