BAIT
UXS1
UGD
UDP-glucuronate decarboxylase 1
GO Process (1)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
AKT1
Akt
v-akt murine thymoma viral oncogene homolog 1
GO Process (81)
GO Function (15)
GO Component (11)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [IDA]
- apoptotic mitochondrial changes [ISO]
- cell projection organization [IDA]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to hypoxia [IDA]
- cellular response to insulin stimulus [IMP, ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [IDA]
- cellular response to peptide [ISO]
- execution phase of apoptosis [ISO]
- germ cell development [ISO]
- glucose homeostasis [ISO]
- glucose metabolic process [ISO]
- glucose transport [ISO]
- glycogen biosynthetic process [IMP]
- glycogen cell differentiation involved in embryonic placenta development [ISO]
- glycogen metabolic process [ISO]
- hyaluronan metabolic process [IEP]
- inflammatory response [ISO]
- insulin receptor signaling pathway [IMP, ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [ISO]
- maternal placenta development [ISO]
- negative regulation of JNK cascade [IDA]
- negative regulation of apoptotic process [ISO, TAS]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [IDA, ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- osteoblast differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [ISO]
- phosphorylation [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [IDA, ISO]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [IMP]
- protein catabolic process [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- protein ubiquitination [ISO]
- regulation of cell migration [IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [ISO]
- regulation of neuron projection development [ISO, ISS]
- regulation of protein localization [IMP, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [ISO]
- response to hormone [ISO]
- response to oxidative stress [ISS]
- signal transduction [IDA]
- striated muscle cell differentiation [ISO]
- translation [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
UDP-glucuronate decarboxylase (UGD) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans. In a yeast two-hybrid screen with the protein kinase Akt (protein kinase B), we detected interactions with a novel sequence, which we cloned and expressed. The expressed protein displayed UGD activity but did not display the ... [more]
J. Biol. Chem. May. 10, 2002; 277(19);16968-75 [Pubmed: 11877387]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID