BAIT
UXS1
UGD
UDP-glucuronate decarboxylase 1
GO Process (1)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
AKT1
Akt
v-akt murine thymoma viral oncogene homolog 1
GO Process (81)
GO Function (15)
GO Component (11)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [IDA]
- apoptotic mitochondrial changes [ISO]
- cell projection organization [IDA]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to hypoxia [IDA]
- cellular response to insulin stimulus [IMP, ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [IDA]
- cellular response to peptide [ISO]
- execution phase of apoptosis [ISO]
- germ cell development [ISO]
- glucose homeostasis [ISO]
- glucose metabolic process [ISO]
- glucose transport [ISO]
- glycogen biosynthetic process [IMP]
- glycogen cell differentiation involved in embryonic placenta development [ISO]
- glycogen metabolic process [ISO]
- hyaluronan metabolic process [IEP]
- inflammatory response [ISO]
- insulin receptor signaling pathway [IMP, ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [ISO]
- maternal placenta development [ISO]
- negative regulation of JNK cascade [IDA]
- negative regulation of apoptotic process [ISO, TAS]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [IDA, ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO, ISS]
- osteoblast differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [ISO]
- phosphorylation [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [IDA, ISO]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [IMP]
- protein catabolic process [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- protein ubiquitination [ISO]
- regulation of cell migration [IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [ISO]
- regulation of neuron projection development [ISO, ISS]
- regulation of protein localization [IMP, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [ISO]
- response to hormone [ISO]
- response to oxidative stress [ISS]
- signal transduction [IDA]
- striated muscle cell differentiation [ISO]
- translation [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO, ISS, TAS]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
UDP-glucuronate decarboxylase (UGD) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans. In a yeast two-hybrid screen with the protein kinase Akt (protein kinase B), we detected interactions with a novel sequence, which we cloned and expressed. The expressed protein displayed UGD activity but did not display the ... [more]
J. Biol. Chem. May. 10, 2002; 277(19);16968-75 [Pubmed: 11877387]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID