P53
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [TAS]
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [IMP, TAS]
- cell death [IMP]
- cellular response to DNA damage stimulus [IDA, IMP]
- cellular response to UV [IBA]
- cellular response to gamma radiation [IMP]
- cellular response to starvation [IMP]
- determination of adult lifespan [IMP]
- ectopic germ cell programmed cell death [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, TAS]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of photoreceptor cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- neuroblast differentiation [IMP]
- neuroblast proliferation [IMP]
- oogenesis [IGI]
- positive regulation of cell cycle [IGI]
- positive regulation of cellular response to X-ray [IMP]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- reciprocal meiotic recombination [IMP]
- regulation of DNA repair [IMP]
- regulation of cell proliferation [IMP]
- regulation of neuron apoptotic process [IBA]
- regulation of organ growth [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase II promoter in response to DNA damage [IMP]
- response to UV [IMP]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
- response to ionizing radiation [IMP]
- response to radiation [IMP, TAS]
- response to starvation [IMP]
- tissue regeneration [IMP]
Gene Ontology Molecular Function- DNA binding [NAS]
- chromatin binding [IBA]
- core promoter binding [IDA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- p53 binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding [IBA]
- sequence-specific DNA binding transcription factor activity [IBA, NAS]
- transcription factor binding [IPI]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [NAS]
- chromatin binding [IBA]
- core promoter binding [IDA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- p53 binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding [IBA]
- sequence-specific DNA binding transcription factor activity [IBA, NAS]
- transcription factor binding [IPI]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
BIP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
BACKGROUND: The tumour suppressor protein p53 is a sequence specific DNA-binding transcription regulator, which exerts its versatile roles in genome protection and apoptosis by affecting the expression of a large number of genes. In an attempt to obtain a better understanding of the mechanisms by which p53 transcription function is regulated, we studied p53 interactions. RESULTS: We identified BIP2 (Bric-a-brac ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| P53 BIP2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | FlyBase | - | |
| P53 BIP2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 443576 |