CTP
Gene Ontology Biological Process
- actin filament bundle assembly [IMP]
- autophagy [IMP]
- chaeta development [IMP]
- chaeta morphogenesis [IMP]
- establishment of mitotic spindle orientation [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- microtubule anchoring at centrosome [IMP]
- microtubule-based movement [ISS]
- neurogenesis [IMP]
- oogenesis [IMP]
- salivary gland cell autophagic cell death [IMP]
- sperm individualization [IMP]
- spermatid nucleus elongation [IMP]
- spermatogenesis [IMP]
- wing disc development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ASCIZ
Gene Ontology Biological Process
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Multivalency regulates activity in an intrinsically disordered transcription factor.
The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays, we developed a model that proposes a concerted role of intrinsic disorder and multiple LC8 binding ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CTP ASCIZ | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
ASCIZ CTP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
ASCIZ CTP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
ASCIZ CTP | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
ASCIZ CTP | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | FlyBase | - | |
CTP ASCIZ | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | FlyBase | - | |
ASCIZ CTP | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |