BAIT
DAG1
156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9
dystroglycan 1 (dystrophin-associated glycoprotein 1)
GO Process (9)
GO Function (8)
GO Component (13)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IDA]
- cytoskeletal anchoring at plasma membrane [IMP]
- extracellular matrix organization [TAS]
- membrane protein ectodomain proteolysis [IDA]
- microtubule anchoring [IMP]
- modulation by virus of host morphology or physiology [IDA]
- negative regulation of MAPK cascade [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of protein kinase B signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA]
- contractile ring [IDA]
- cytoplasm [IDA]
- dystrophin-associated glycoprotein complex [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lamellipodium [IDA]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
Homo sapiens
PREY
AGRN
CMSPPD, RP11-54O7.13-009
agrin
GO Process (19)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- clustering of voltage-gated sodium channels [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of synaptic growth at neuromuscular junction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- receptor clustering [IDA, IMP]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synapse organization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor.
Aggregation of acetylcholine receptors (AChRs) on skeletal muscle fibers is thought to be mediated by the basal lamina protein agrin. Structural similarities shared by agrin and laminin suggested that the laminin receptor dystroglycan-alpha, part of a dystrophin-receptor complex, might also bind agrin. We show here that dystroglycan-alpha and dystrophin-related protein (DRP/utrophin) are concentrated within AChR aggregates in cultures of C2 ... [more]
Cell Jun. 03, 1994; 77(5);675-86 [Pubmed: 8205617]
Throughput
- Low Throughput
Curated By
- BioGRID