BAIT
C4A
C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DAMC-258G8.6
complement component 4A (Rodgers blood group)
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CST3
ARMD11
cystatin C
GO Process (10)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- defense response [IDA]
- extracellular fibril organization [IGI]
- negative regulation of blood vessel remodeling [IEP]
- negative regulation of collagen catabolic process [IEP]
- negative regulation of elastin catabolic process [IMP]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of extracellular matrix disassembly [IC, IEP]
- negative regulation of peptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- regulation of tissue remodeling [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction.
Hydropathic anticomplementarity of amino acids indicates that peptides derived from complementary DNA strands may form amphiphilic structures and bind one another. By using this concept, we have found that the antisense peptide Ser-Tyr-Asp-Leu complementary to the segment Gln-Ile-Val-Ala-Gly (residues 55-59) in cystatin C (an inhibitor of cysteine proteases) is located at positions 611-614 of the beta chain of human C4, ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 01, 1990; 87(4);1288-91 [Pubmed: 2304899]
Throughput
- Low Throughput
Curated By
- BioGRID