C4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CST3
Gene Ontology Biological Process
- defense response [IDA]
- extracellular fibril organization [IGI]
- negative regulation of blood vessel remodeling [IEP]
- negative regulation of collagen catabolic process [IEP]
- negative regulation of elastin catabolic process [IMP]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of extracellular matrix disassembly [IC, IEP]
- negative regulation of peptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- regulation of tissue remodeling [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction.
Hydropathic anticomplementarity of amino acids indicates that peptides derived from complementary DNA strands may form amphiphilic structures and bind one another. By using this concept, we have found that the antisense peptide Ser-Tyr-Asp-Leu complementary to the segment Gln-Ile-Val-Ala-Gly (residues 55-59) in cystatin C (an inhibitor of cysteine proteases) is located at positions 611-614 of the beta chain of human C4, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID