BAIT
CTPSYN
CG45070, CG6854, CTPS, Dmel\CG45070, Dmel_CG6854, Dmel_CG45070
CTP synthase
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
CTPSYN
CG45070, CG6854, CTPS, Dmel\CG45070, Dmel_CG6854, Dmel_CG45070
CTP synthase
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The proline synthesis enzyme P5CS forms cytoophidia in Drosophila.
Compartmentation of enzymes via filamentation has arisen as a mechanism for the regulation of metabolism. In 2010, three groups independently reported that CTP synthase (CTPS) can assemble into a filamentous structure termed the cytoophidium. In searching for CTPS-interacting proteins, here we perform a yeast two-hybrid screening of Drosophila proteins and identify a putative CTPS-interacting protein, ?1-pyrroline-5-carboxylate synthase (P5CS). Using the ... [more]
J Genet Genomics Dec. 20, 2019; 47(3);131-143 [Pubmed: 32317150]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CTPSYN CTPSYN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |