BAIT

CTPSYN

CG45070, CG6854, CTPS, Dmel\CG45070, Dmel_CG6854, Dmel_CG45070
CTP synthase
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Drosophila melanogaster
PREY

CTPSYN

CG45070, CG6854, CTPS, Dmel\CG45070, Dmel_CG6854, Dmel_CG45070
CTP synthase
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Drosophila melanogaster

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The proline synthesis enzyme P5CS forms cytoophidia in Drosophila.

Zhang B, Tastan OeY, Zhou X, Guo CJ, Liu X, Thind A, Hu HH, Zhao S, Liu JL

Compartmentation of enzymes via filamentation has arisen as a mechanism for the regulation of metabolism. In 2010, three groups independently reported that CTP synthase (CTPS) can assemble into a filamentous structure termed the cytoophidium. In searching for CTPS-interacting proteins, here we perform a yeast two-hybrid screening of Drosophila proteins and identify a putative CTPS-interacting protein, ?1-pyrroline-5-carboxylate synthase (P5CS). Using the ... [more]

J Genet Genomics Dec. 20, 2019; 47(3);131-143 [Pubmed: 32317150]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CTPSYN CTPSYN
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

High-BioGRID
-

Curated By