BAIT
RBP1
CG17136, Dmel\CG17136, RRM1, RRM11, Rbp-1, Rbp11, Dmel_CG17136
RNA-binding protein 1
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
TRA2
CG10128, Dmel\CG10128, TRA 2, TRA-2, Dmel_CG10128
transformer 2
GO Process (11)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- female sex determination [IMP]
- female somatic sex determination [NAS, TAS]
- mRNA processing [IMP, NAS]
- mRNA splicing, via spliceosome [IC, IDA]
- male somatic sex determination [TAS]
- regulation of alternative mRNA splicing, via spliceosome [IDA, IMP]
- regulation of mRNA splicing, via spliceosome [IDA]
- reproduction [IMP]
- sex determination [NAS]
- spermatogenesis [NAS]
- spliceosomal complex assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.
The activation of sex-specific alternative splice sites in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on the serine-arginine-rich (SR) splicing factors Tra, Tra2, and Rbp1. Little is known, however, about how SR factors negatively regulate splice sites in other RNAs. Here we examine how Tra2 blocks splicing of the M1 intron from its own ... [more]
Mol Cell Biol Jan. 01, 2007; 27(2);699-708 [Pubmed: 17101798]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TRA2 RBP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |