RGS14
Gene Ontology Biological Process
- cell division [IMP]
- chromosome segregation [ISS]
- intracellular signal transduction [ISS]
- learning [ISS]
- long-term memory [ISS]
- long-term synaptic potentiation [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of synaptic plasticity [ISS]
- nucleocytoplasmic transport [ISS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of GTPase activity [IBA, IDA, TAS]
- positive regulation of neurogenesis [ISS]
- regulation of DNA-templated transcription in response to stress [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- response to oxidative stress [ISS]
- spindle organization [IMP]
- visual learning [ISS]
- zygote asymmetric cell division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAP1A
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- nerve growth factor signaling pathway [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of Rap GTPase activity [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of vasculogenesis [ISS]
- protein transport [IDA]
- regulation of cell junction assembly [IMP]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
In an attempt to elucidate the physiological function(s) of the Ras-related Rap proteins, we used the yeast two-hybrid system and isolated a cDNA encoding a protein that interacts with both Rap1 and Rap2, but not with Ras; the use of Rap2 mutants showed that this interaction is characteristic of a potential Rap effector. This protein was identified as RGS14, a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID