FOXG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
FOXH1
Gene Ontology Biological Process
- negative regulation of androgen receptor activity [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of intracellular estrogen receptor signaling pathway [IDA]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- transforming growth factor beta receptor signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- R-SMAD binding [IMP, IPI]
- SMAD binding [IPI]
- androgen receptor binding [IPI]
- bHLH transcription factor binding [IPI]
- co-SMAD binding [IMP]
- enhancer binding [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription regulatory region DNA binding [ISS]
- DNA binding [IDA]
- R-SMAD binding [IMP, IPI]
- SMAD binding [IPI]
- androgen receptor binding [IPI]
- bHLH transcription factor binding [IPI]
- co-SMAD binding [IMP]
- enhancer binding [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.
The winged-helix (WH) BF-1 gene, which encodes brain factor 1 (BF-1) (also known as foxg1), is essential for the proliferation of the progenitor cells of the cerebral cortex. Here we show that BF-1-deficient telencephalic progenitor cells are more apt to leave the cell cycle in response to transforming growth factor beta (TGF-beta) and activin. We found that ectopic expression of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXG1 FOXH1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID