BAIT
TWIST2
DERMO1, FFDD3, SETLSS, bHLHa39
twist family bHLH transcription factor 2
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MEF2C
C5DELq14.3, DEL5q14.3
myocyte enhancer factor 2C
GO Process (98)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- MAPK cascade [IDA, IMP]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cardiac ventricle formation [ISS]
- cell morphogenesis involved in neuron differentiation [ISS]
- cellular response to calcium ion [ISS]
- cellular response to drug [ISS]
- cellular response to fluid shear stress [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to parathyroid hormone stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to trichostatin A [ISS]
- chondrocyte differentiation [ISS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in renal tubule morphogenesis [ISS]
- germinal center formation [ISS]
- glomerulus morphogenesis [ISS]
- heart development [IEP, ISS, NAS]
- heart looping [ISS]
- humoral immune response [ISS]
- innate immune response [TAS]
- learning or memory [ISS]
- melanocyte differentiation [ISS]
- muscle cell differentiation [TAS]
- muscle cell fate determination [ISS]
- muscle organ development [TAS]
- myotube differentiation [IEP]
- negative regulation of gene expression [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of ossification [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nephron tubule epithelial cell differentiation [ISS]
- nervous system development [TAS]
- neural crest cell differentiation [ISS]
- neuron development [ISS]
- neuron differentiation [IEP, ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoblast differentiation [ISS]
- outflow tract morphogenesis [ISS]
- platelet formation [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of behavioral fear response [ISS]
- positive regulation of bone mineralization [ISS]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of neuron differentiation [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of protein homodimerization activity [ISS]
- positive regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of skeletal muscle tissue development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- primary heart field specification [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of dendritic spine development [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of germinal center formation [ISS]
- regulation of megakaryocyte differentiation [ISS]
- regulation of neuron apoptotic process [ISS]
- regulation of neurotransmitter secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic activity [ISS]
- regulation of synaptic plasticity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of transcription, DNA-templated [IDA]
- renal tubule morphogenesis [ISS]
- response to ischemia [ISS]
- response to virus [IEP]
- secondary heart field specification [ISS]
- sinoatrial valve morphogenesis [ISS]
- skeletal muscle tissue development [ISS]
- smooth muscle cell differentiation [ISS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [IDA, ISS]
- ventricular cardiac muscle cell differentiation [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.
Dermo-1 is a multifunctional basic helix-loop-helix (bHLH) transcription factor that has been shown to be a potent negative regulator for gene transcription and apoptosis. To understand the molecular mechanisms that mediate the function of Dermo-1, we generated a series of Dermo-1 mutants and used a MyoD-mediated transcriptional activation model to characterize the roles of its N-terminal, bHLH, and C-terminal structural ... [more]
J. Biol. Chem. Apr. 05, 2002; 277(14);12310-7 [Pubmed: 11809751]
Throughput
- Low Throughput
Curated By
- BioGRID