BAIT
HOXB9
HOX-2.5, HOX2, HOX2E
homeobox B9
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BTG1
B-cell translocation gene 1, anti-proliferative
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cell migration [NAS]
- negative regulation of cell growth [NAS]
- negative regulation of cell proliferation [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of fibroblast apoptotic process [IMP]
- positive regulation of myoblast differentiation [IDA, NAS]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation.
BTG1 and BTG2 belong to a family of functionally related genes involved in the control of the cell cycle. As part of an ongoing attempt to understand their biological functions, we used a yeast two-hybrid screening to look for possible functional partners of Btg1 and Btg2. Here we report the physical and functional association between these proteins and the homeodomain ... [more]
J. Biol. Chem. Jan. 07, 2000; 275(1);147-53 [Pubmed: 10617598]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOXB9 BTG1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID