BAIT
MLLT4
AF6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NRXN2
neurexin 2
GO Process (12)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
- adult behavior [IMP]
- gephyrin clustering [ISS]
- neuroligin clustering [ISS]
- neuron cell-cell adhesion [TAS]
- neurotransmitter secretion [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- social behavior [IMP]
- synapse assembly [ISS]
- synaptic transmission [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.
Eph-related receptor tyrosine kinases (RTKs) have been implicated in intercellular communication during embryonic development. To elucidate their signal transduction pathways, we applied the yeast two-hybrid system. We could demonstrate that the carboxyl termini of the Eph-related RTKs EphA7, EphB2, EphB3, EphB5, and EphB6 interact with the PDZ domain of the ras-binding protein AF6. A mutational analysis revealed that six C-terminal ... [more]
Proc. Natl. Acad. Sci. U.S.A. Aug. 18, 1998; 95(17);9779-84 [Pubmed: 9707552]
Throughput
- Low Throughput
Curated By
- BioGRID