BAIT
NCK2
GRB4, NCKbeta
NCK adaptor protein 2
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T cell activation [NAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of cell proliferation [TAS]
- positive regulation of T cell proliferation [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermal growth factor-activated receptor activity [TAS]
- signal complex assembly [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DOCK1
DOCK180, ced5, RP11-82L9.1
dedicator of cytokinesis 1
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.
Nck-2 is a newly identified adapter protein comprising three N-terminal SH3 domains and one C-terminal SH2 domain. We have identified in a yeast two-hybrid screen DOCK180, a signaling protein implicated in the regulation of membrane ruffling and migration, as a binding protein for Nck-2. Surface plasmon resonance analyses reveal that the second and the third SH3 domains interact with the ... [more]
FEBS Lett. Mar. 02, 2001; 491(3);193-9 [Pubmed: 11240126]
Throughput
- Low Throughput
Curated By
- BioGRID