BAIT
LRRC59
p34, PRO1855
leucine rich repeat containing 59
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCARB1
CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1
scavenger receptor class B, member 1
GO Process (24)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- adhesion of symbiont to host [IMP]
- cholesterol efflux [ISS]
- cholesterol homeostasis [ISS]
- cholesterol import [ISS]
- detection of lipopolysaccharide [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [ISS]
- lipopolysaccharide transport [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle clearance [ISS]
- phospholipid transport [ISS]
- positive regulation of cholesterol storage [IDA]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of triglyceride biosynthetic process [ISS]
- receptor-mediated endocytosis [IDA]
- recognition of apoptotic cell [IDA]
- regulation of phagocytosis [IC]
- regulation of phosphatidylcholine catabolic process [ISS]
- reverse cholesterol transport [IEP]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane.
Protein synthesis on the endoplasmic reticulum (ER) requires the dynamic coordination of numerous cellular components. Together, resident ER membrane proteins, cytoplasmic translation factors, and both integral membrane and cytosolic RNA-binding proteins operate in concert with membrane-associated ribosomes to facilitate ER-localized translation. Little is known, however, regarding the spatial organization of ER-localized translation. This question is of growing significance as it ... [more]
Mol Cell Proteomics Aug. 11, 2020; (); [Pubmed: 32788342]
Throughput
- High Throughput
Curated By
- BioGRID