BAIT
LRRC59
p34, PRO1855
leucine rich repeat containing 59
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MSH6
GTBP, GTMBP, HNPCC5, HSAP, p160
mutS homolog 6
GO Process (15)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- DNA repair [IDA]
- determination of adult lifespan [ISS]
- intrinsic apoptotic signaling pathway [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA, ISS]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- meiotic mismatch repair [IBA, ISS]
- mismatch repair [IDA, IGI, IMP]
- negative regulation of DNA recombination [IDA]
- positive regulation of helicase activity [IDA]
- reciprocal meiotic recombination [IBA]
- response to UV [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA, ISS]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- magnesium ion binding [IDA]
- methylated histone binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- magnesium ion binding [IDA]
- methylated histone binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane.
Protein synthesis on the endoplasmic reticulum (ER) requires the dynamic coordination of numerous cellular components. Together, resident ER membrane proteins, cytoplasmic translation factors, and both integral membrane and cytosolic RNA-binding proteins operate in concert with membrane-associated ribosomes to facilitate ER-localized translation. Little is known, however, regarding the spatial organization of ER-localized translation. This question is of growing significance as it ... [more]
Mol Cell Proteomics Aug. 11, 2020; (); [Pubmed: 32788342]
Throughput
- High Throughput
Curated By
- BioGRID