BAIT
NR0B1
AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2
nuclear receptor subfamily 0, group B, member 1
GO Process (13)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- adrenal gland development [IMP]
- gene expression [TAS]
- gonad development [IMP]
- hypothalamus development [NAS]
- intracellular receptor signaling pathway [IDA, NAS]
- male gonad development [IMP]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- pituitary gland development [NAS]
- protein localization [IDA]
- steroid biosynthetic process [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AF-2 domain binding [IPI]
- DNA binding [IDA]
- DNA hairpin binding [IDA]
- RNA binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- steroid hormone receptor binding [IPI]
- transcription corepressor activity [IMP]
- transcription factor binding [IPI]
- AF-2 domain binding [IPI]
- DNA binding [IDA]
- DNA hairpin binding [IDA]
- RNA binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- steroid hormone receptor binding [IPI]
- transcription corepressor activity [IMP]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
NRIP1
RIP140
nuclear receptor interacting protein 1
GO Process (6)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- circadian regulation of gene expression [IMP]
- circadian rhythm [IEP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1.
Coregulators have been suggested to act as a bridging apparatus between nuclear receptors and the transcriptional machinery. The orphan receptor SF-1 plays a role in controlling the basal and cAMP-stimulated expression of the human steroidogenic acute regulatory protein gene. DAX-1 is the gene responsible for X-linked adrenal hypoplasia congenita and blocks steroid biosynthesis by impairing the expression of steroidogenic acute ... [more]
Endocrinology Aug. 01, 2001; 142(8);3570-7 [Pubmed: 11459805]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NRIP1 NR0B1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID