BAIT
SERPINE1
PAI, PAI-1, PAI1, PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (34)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [IEP]
- blood coagulation [TAS]
- cellular response to lipopolysaccharide [IMP]
- chronological cell aging [IEP]
- defense response to Gram-negative bacterium [IGI]
- extracellular matrix organization [TAS]
- fibrinolysis [TAS]
- gene expression [TAS]
- negative regulation of blood coagulation [IC]
- negative regulation of cell adhesion mediated by integrin [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fibrinolysis [IDA]
- negative regulation of plasminogen activation [IDA, IMP]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IDA]
- negative regulation of vascular wound healing [IGI]
- negative regulation of wound healing [IC]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of leukotriene production involved in inflammatory response [IMP]
- positive regulation of monocyte chemotaxis [IMP]
- positive regulation of receptor-mediated endocytosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of receptor activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLAT
T-PA, TPA
plasminogen activator, tissue
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1.
Fibrinolysis is regulated in part by the interaction between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1, a serine protease inhibitor of the serpin family). It is known from our earlier work that deletion of a loop of amino acids (residues 296-302) from the serine protease domain of t-PA suppresses the interaction between the two proteins without altering ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 01, 1990; 87(9);3530-3 [Pubmed: 2110366]
Throughput
- Low Throughput
Curated By
- BioGRID