BAIT
NBN
AT-V1, AT-V2, ATV, NBS, NBS1, P95
nibrin
GO Process (13)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA damage response, signal transduction by p53 class mediator [TAS]
- DNA duplex unwinding [IMP]
- DNA repair [TAS]
- cell cycle arrest [TAS]
- double-strand break repair [IDA, TAS]
- double-strand break repair via homologous recombination [TAS]
- mitotic G2 DNA damage checkpoint [IDA]
- mitotic cell cycle checkpoint [IDA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- regulation of DNA-dependent DNA replication initiation [TAS]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TERF1
PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1
telomeric repeat binding factor (NIMA-interacting) 1
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IEP]
- age-dependent telomere shortening [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of DNA replication [IDA]
- negative regulation of telomerase activity [IGI]
- negative regulation of telomere maintenance via semi-conservative replication [NAS]
- negative regulation of telomere maintenance via telomerase [IGI]
- positive regulation of apoptotic process [IDA]
- positive regulation of microtubule polymerization [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein homooligomerization [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.
Nijmegen breakage syndrome, a chromosomal instability disorder, is characterized in part by cellular hypersensitivity to ionizing radiation. The NBS1 gene product, p95 (NBS1 or nibrin) forms a complex with Rad50 and Mre11. Cells deficient in the formation of this complex are defective in DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. How the NBS1 complex is ... [more]
J. Biol. Chem. Sep. 29, 2000; 275(39);30618-22 [Pubmed: 10913111]
Throughput
- Low Throughput
Curated By
- BioGRID