Amphiphysin I and II are nerve terminal-enriched proteins containing SH3 domains that interact with dynamin and synaptojanin. The amphiphysins may function in synaptic vesicle endocytosis by targeting synaptojanin and dynamin to emerging endocytic buds through SH3 domain-independent interactions with clathrin and AP2. We have recently identified and cloned several amphiphysin II splice variants that differentially incorporate clathrin-binding domains. To determine ... [more]

J. Biol. Chem. Jul. 09, 1999; 274(28);19785-91 [Pubmed: 10391921]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

BIN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase binding [IPI]identical protein binding [IPI]protein binding [IPI]tau protein binding [IPI]

Gene Ontology Cellular Component

BIN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase binding [IPI]identical protein binding [IPI]protein binding [IPI]tau protein binding [IPI]

Gene Ontology Cellular Component

Reconstituted Complex

Publication

The N terminus of amphiphysin II mediates dimerization and plasma membrane targeting.

Throughput

Curated By

RNA polymerase binding [IPI]
identical protein binding [IPI]
protein binding [IPI]
tau protein binding [IPI]

RNA polymerase binding [IPI]
identical protein binding [IPI]
protein binding [IPI]
tau protein binding [IPI]