BAIT
CDC42
CDC42Hs, G25K, RP1-224A6.5
cell division cycle 42
GO Process (25)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- GTP catabolic process [TAS]
- Golgi organization [ISS]
- T cell costimulation [TAS]
- actin cytoskeleton organization [IDA]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of Golgi localization [ISS]
- establishment or maintenance of cell polarity [TAS]
- innate immune response [TAS]
- macrophage differentiation [TAS]
- muscle cell differentiation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of protein complex assembly [IPI]
- organelle transport along microtubule [ISS]
- positive regulation of cytokinesis [IMP]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of attachment of spindle microtubules to kinetochore [IMP]
- regulation of filopodium assembly [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISS]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [IDA]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- midbody [IDA]
- mitotic spindle [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- plasma membrane [IDA, TAS]
- spindle midzone [IDA]
Homo sapiens
PREY
TMED10
P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23
transmembrane emp24-like trafficking protein 10 (yeast)
GO Process (10)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- COPI coating of Golgi vesicle [TAS]
- COPI-coated vesicle budding [IDA]
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- cargo loading into vesicle [TAS]
- intracellular protein transport [IDA]
- regulated secretory pathway [ISS]
- regulation of beta-amyloid formation [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
- vesicle targeting, to, from or within Golgi [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COPI-coated vesicle [ISS]
- Golgi apparatus [IDA]
- Golgi membrane [IDA, TAS]
- cis-Golgi network [ISS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- gamma-secretase complex [IDA]
- integral component of membrane [ISS]
- plasma membrane [ISS]
- secretory granule membrane [ISS]
- trans-Golgi network transport vesicle [ISS]
- zymogen granule membrane [ISS]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3? as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.
Cdc42, a member of the Rho GTPase family, is an intracellular signaling protein known for its roles in cytoskeleton rearrangements and, more recently, in apoptosis/senescence triggered by genotoxic stress. In some tumor cells, the overactivation of Cdc42 through the expression of constitutively active mutants (G12V or Q61L), GEF activation, or GAP downregulation functions as an antiproliferative or pro-aging mechanism. In ... [more]
J Proteome Res Dec. 04, 2018; 18(10);3597-3614 [Pubmed: 31478661]
Throughput
- High Throughput
Curated By
- BioGRID