BAIT

NMRAL1

HSCARG, SDR48A1
NmrA-like family domain containing 1
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens
PREY

CAPZA2

CAPPA2, CAPZ
capping protein (actin filament) muscle Z-line, alpha 2
GO Process (4)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.

Zang W, Yang C, Li T, Liao L, Zheng X

The translesion synthesis (TLS) pathway is a double-edged sword in terms of genome integrity. Deficiency in TLS leads to generation of DNA double strand break (DSB) during replication stress, while excessive activation of the TLS pathway increases the risk of point mutation. Here we demonstrate that HSCARG, a cellular redox sensor, directly interacts with the key protein PCNA in the ... [more]

Proc Natl Acad Sci U S A Dec. 17, 2018; 116(51);25624-25633 [Pubmed: 31796584]

Throughput

  • High Throughput

Curated By

  • BioGRID