SUMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
MSH6
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- DNA repair [IDA]
- determination of adult lifespan [ISS]
- intrinsic apoptotic signaling pathway [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA, ISS]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- meiotic mismatch repair [IBA, ISS]
- mismatch repair [IDA, IGI, IMP]
- negative regulation of DNA recombination [IDA]
- positive regulation of helicase activity [IDA]
- reciprocal meiotic recombination [IBA]
- response to UV [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA, ISS]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- magnesium ion binding [IDA]
- methylated histone binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- double-stranded DNA binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- magnesium ion binding [IDA]
- methylated histone binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.
Post-translational modification with the small ubiquitin-like modifier (SUMO) affects thousands of proteins in the human proteome and is implicated in numerous cellular processes. The main outcome of SUMO conjugation is a rewiring of protein-protein interactions through recognition of the modifier's surface by SUMO binding proteins. The SUMO-interacting motif (SIM) mediates binding to a groove on SUMO; however, the low affinity ... [more]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID