MRE11A
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA duplex unwinding [IMP]
- DNA recombination [TAS]
- DNA repair [TAS]
- base-excision repair [IBA]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IBA, TAS]
- double-strand break repair via homologous recombination [TAS]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IBA]
- negative regulation of DNA endoreduplication [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA, TAS]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of type I interferon production [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [TAS]
- sister chromatid cohesion [IMP]
- telomere maintenance [IBA]
- telomere maintenance via telomerase [TAS]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
Gene Ontology Cellular Component
SUMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.
Post-translational modification with the small ubiquitin-like modifier (SUMO) affects thousands of proteins in the human proteome and is implicated in numerous cellular processes. The main outcome of SUMO conjugation is a rewiring of protein-protein interactions through recognition of the modifier's surface by SUMO binding proteins. The SUMO-interacting motif (SIM) mediates binding to a groove on SUMO; however, the low affinity ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUMO2 MRE11A | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | - | BioGRID | 2878295 | |
| SUMO2 MRE11A | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | - | BioGRID | 1101221 |
Curated By
- BioGRID